Ellagic acid attenuated the UV-B-induced toxicity of HaCaT keratinocytes and human dermal fibroblasts. Find NCBI SARS-CoV-2 literature, sequence, and clinical content: https://www.ncbi.nlm.nih.gov/sars-cov-2/. The most plentiful food sources of EA are blackberries, cranberries, pecans, pomegranates, purple/red grapes, raspberries, strawberries and walnuts. Dear Soko: What’s the Best Way to Use Pimple Patches? Mitani H, Naru E, Yamashita M, Arakane K, Suzuki T, Imanari T. Photodermatol Photoimmunol Photomed. It is a natural phenol antioxidant usually found in fruits and vegetables. Other ellagic acid health benefits and uses include the prevention and treatment of certain cancers, obesity, obesity-related metabolic problems, viral infections and DNA damage. Rarely highlighted as the focal point of any skincare products that contain it, ellagic acid was recently studied by Korean researchers looking to confirm its anti-aging abilities. BACKGROUND: Dietary modification, through supplementation and elimination diets, has become an area of interest to help slow skin aging, reduce symptom severity or prevent reoccurrence of certain dermatologic conditions [Clinical Dermatology vol. During the course of the 4 week study, female volunteers using the EA all demonstrated evidence of UV protection. Anti-wrinkle activity of ellagic acid was further investigated in hairless mice exposed to UV-B, in which it attenuated UV-B-triggered skin wrinkle formation and epidermal thickening. A statistically significant difference was observed between mean differences from baseline scores for total wrinkle count at week 4 for the combination active groups compared to placebo. In 2006, a trial showed that an EA-rich pomegranate extract protected the skin of women exposed to slight sunburning conditions. Got Skin Care Goals? Common sources include strawberries, raspberries, cranberries, and pomegranates,” says Dr. Michele Farber, a board-certified dermatologist at NYC’s Schweiger Dermatology Group. | There’s also some documentation about the dermatological benefits of orally administered ellagic acid. “[Further], ellagic acid may interfere with enzymes that damage collagen, which means reduced wrinkling and improvement in pigment,” says Dr. Farber. Therefore, dietary and pharmacological interventions with berries rich in ellagic acid may be promising treatment strategies interrupting skin wrinkle and inflammation associated with chronic UV exposure leading to photoageing. In fact, it’s considered a gentler, pregnancy-approved alternative to hydroquinone. The use of antioxidant-related therapies such as nutraceuticals is of particular interest in restoring skin homeostasis. Ellagic Acid Recovery by Solid State Fermentation of Pomegranate Wastes by. NCI CPTC Antibody Characterization Program. Photochem Photobiol. This site needs JavaScript to work properly. J Investig Dermatol Symp Proc. Here are the Best of K-Beauty™ Winners That’ll Help, The Double Cleansing Myths You Need to Stop Believing, How My Skincare Routine Changed As I Approach My Late 20s, Why We’re Gung-Ho About the Pimple Patch Trend. But a more serious concern is that of skin cancer. Half of the mice had EA applied to their skin daily. The scientists first tested the effects of EA on human skin cells that were exposed to ultraviolet damage (a “sunburn” model). 2006 Mar-Apr;82(2):574-8. doi: 10.1562/2005-07-26-RA-623. 2009 Aug;14(1):36-43. doi: 10.1038/jidsymp.2009.11. Ellagic acid — technically a polyphenol — is neither of those; instead it is an antioxidant-loaded that protects and brightens your skin. 76,77 These molecules are receiving attention as agents that may have potential bioactivities preventing chronic … CONCLUSION: We have shown that the combination of zeaxanthin-based dietary supplement plus a topical formulation produces superior hydration to that of placebo. 2009 Jan 5;602(1):148-56. doi: 10.1016/j.ejphar.2008.11.021. The study consisted of a washout visit, baseline (randomization), week two (2), week four (4), week six (6), week eight (8), and week twelve (12). A brand new Korean study reported at the April 2009 Experimental Biology Meeting discusses the potential of a topical form of ellagic acid in the management of wrinkles. 2004 Oct;20(5):215-23. doi: 10.1111/j.1600-0781.2004.00116.x. This finding coupled with a significant increase in sebum, hydration and tonicity, if compared with placebo. The mice who received high exposure to UV radiation developed thicker skin and wrinkles. The improvement in facial photoaging also coupled with an increase in serum fibronectin and HA and a decrease in serum carbonylated proteins and neutrophil elastase 2. Antioxidant carotenoid zeaxanthin is concentrated in the eye and skin tissue and believed to decrease the formation of ROS associated with UV light exposure. “Each acid has a different effect on the skin, so they are good in conjunction. Ellagic acid benefits for skin include a possible reduction in wrinkles and inflammation caused by UV exposure. The foods we eat contain a multitude of chemicals that we’re often not aware of. A recent Korean study shows that ellagic acid applied to sun damaged skin (a mild sunburn) reduced inflammation. A group of hairless mice, with skin characteristics similar to humans, were also exposed to excessive UV radiation over the course of 8 weeks. Berry Powerful Wrinkle Fighter Ellagic acid (EA) is a type of antioxidant referred to as a “polyphenol”. (It becomes unpaired through pollution and the sun.) Ellagic acid, a polyphenol compound present in berries and pomegranate, has received attention as an agent that may have potential bioactivities preventing chronic diseases. Incorporating foods and supplements that contain EA into a wellness routine may support the skin from the inside out. USA.gov. This study examined photoprotective effects of ellagic acid on collagen breakdown and inflammatory responses in UV (ultraviolet)-B irradiated human skin cells and hairless mice. If you’re interested in trying ellagic acid yourself, you’ve got a few excellent options. Hands down, ellagic acid’s biggest claim to fame is its antioxidant properties. Clipboard, Search History, and several other advanced features are temporarily unavailable. Get the latest research from NIH: https://www.nih.gov/coronavirus. With dermatologist insight, we’re giving you the 411 on what ellagic acid is, what its primary skin care benefits are, and which skin types benefit most from using it. Get the latest public health information from CDC: https://www.coronavirus.gov. But it’s important to remember that virtually every aspect of health is impacted by diet. To better understand what that means, it’s important to have a rough idea of what free radicals are in the first place. The study, published in the journal Basic Life Science found that ellagic acid (and other polyphenols found in similar foods) may inhibit skin tumors at various stages of their typical life cycle. Share them in the comments below! The dosages used were 100mg, 200mg of ellagic acid a day or a placebo. Ellagic acid binds to cancer-causing chemicals and can prevent the formation of cancer cells. Recent advances in characterizing biological mechanisms underlying UV-induced wrinkles: a pivotal role of fibrobrast-derived elastase. The clinical meaning of these parameters and their involvement in the photoaging pathophysiology at the systemic level warrant further investigation. doi: 10.1007/s00403-007-0798-x. The study was set up in two separate parts: The results of these experiments offer hope in the battle against premature skin aging. But this is a unique substance, in that it helps whether you consume it in a food/supplement form or apply it directly to the skin. Antioxidants serve as a shield by neutralizing the chaos of the unpaired atom so that it doesn’t wreak havoc. Moccia F, Flores-Gallegos AC, Chávez-González ML, Sepúlveda L, Marzorati S, Verotta L, Panzella L, Ascacio-Valdes JA, Aguilar CN, Napolitano A. Molecules. Update: Dietary supplement improves appearance, health of aging skin …, http://www.sciencedirect.com/science/article/pii/S101113441400390X, Journal of Photochemistry and Photobiology B: Biology; Volume 144, March 2015, A dietary supplement improves facial photoaging and skin sebum, hydration and tonicity modulating serum fibronectin, neutrophil elastase 2, hyaluronic acid and carbonylated proteins, “In the present study, administration of a dietary supplement containing Pycnogenol®, low-molecular-weight HA, collagen, glucosamine sulfate, chondroitin sulfate and coenzyme Q10 significantly improved facial photoaging, as assessed 2 weeks after the end of a 4-week treatment period. Pomegranate Juice and Extract Consumption Increases the Resistance to UVB-induced Erythema and Changes the Skin Microbiome in Healthy Women: a Randomized Controlled Trial. “While more research is being done on ellagic acid to … 2020 Feb;42(1):271-285. doi: 10.1007/s11357-019-00135-6. Currently there are not a lot of ellagic acid creams and lotions on the market. Ellagic acid is an example of a regularly consumed phytochemical (plant chemical) that may very well contribute to the betterment of our health. Mechanism of UVB-induced wrinkling of the skin: paracrine cytokine linkage between keratinocytes and fibroblasts leading to the stimulation of elastase. Ellagic acid (EA) and tannic acid (TA) are phenolic acids found in a wide variety of fruits and nuts such as raspberries, strawberries, pomegranate, walnuts, grapes, and blackcurrants. It may seem like the skin care market is stuffed to the max with a million different acids — the most common being hyaluronic, salicylic, glycolic, and lactic. “While more research is being done on ellagic acid to elucidate all of its uses and potential side effects, it definitely has many positive skin benefits and is likely a more potent antioxidant.”. Pycnogenol®, HA, collagen, glucosamine sulfate, chondroitin sulfate and coenzyme Q10, which all possess a rationale of efficacy in modulating the ECM, can be put together in a dietary compound that produces an improvement in skin photoaging also modulating serum HA, carbonylated proteins, fibronectin and neutrophil elastase 2 levels. That said, Dr. Farber notes that ellagic acid is especially worthy of your regimen if your end goal is to curb premature aging and/or to address pigment issues. The results from this study are in agreement with a previous investigation where a dietary formulation (BioCell Collagen®) administered for 12 weeks improved skin dryness/scaling and global lines/wrinkles with a significant increase in hemoglobin and collagen in skin dermis at 6 weeks and hemoglobin at the end of the study [16]. The question many people have is, “How do we really know if something is healthy for us?”. Here are the primary findings that were reported: Collectively, this evidence reveals that ellagic acid may combat wrinkles by protecting the collagen in skin tissue and reducing inflammation. Kharat P, Sarkar P, Mouliganesh S, Tiwary V, Priya VBR, Sree NY, Annapoorna HV, Saikia DK, Mahanta K, Thirumurugan K. Geroscience.
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